An exploration group led by Dr. Ho Sang Jung of the Surface and Nano Materials Division of the Korea Organization of Materials Science (KIMS), an exploration establishment under the Service of Science and ICT, led a joint examination with Teacher Junsuk Rho of POSTECH and Teacher Samjin Choi of Kyung Hee College Clinical School to track down metabolites in pee and foster a strip-type pee sensor that can enhance the light sign of those metabolites to analyze disease.
This innovation can be applied to the diagnosis of prostate disease and pancreatic malignant growth without an extra examination process by illuminating a small volume (10 uL) of pee. The test device is designed as a strip to detect malignant growth quickly and with high responsiveness.
The exploration group zeroed in on the distinction in metabolomic parts present in the urine of disease patients versus malignant growth-free patients. At the point when disease cells multiply in the body, they emit various metabolites into pee because of unusual digestion. To arrange these, costly and huge gear was required, restricting nearby field applications.
The exploration group fostered a surface-improved Raman dispersing sensor that enhances the optical sign of metabolites in pee more than 1 billion times by framing a coral-molded plasmonic nanomaterial on permeable paper. At the point when pee is dropped into the sensor and light is illuminated, malignant growth metabolite signals are enhanced on the sensor surface, making it conceivable to analyze disease. The research team used a man-made reasoning-based examination strategy to the obtained unearthly sign and was successful in recognizing the vast majority of prostate malignant growth and pancreatic disease in patients.
Various currently used conclusion procedures, such as blood tests, radiological strategies, and histological examination, detect the presence of disease.Many people attempt to track the progression of disease through yearly wellness exams; however, malignant growth is typically detected late and treatment is postponed.This study utilized pee, an organic example that can be effectively obtained. It could be used for both new disease detection via on-site quick malignant growth patient screening and repeat monitoring following malignant growth treatment.Furthermore, because the strip-type sensor’s production cost is less than 100 KRW (around $0.08 USD) per unit, it is likely that it will be used for mass testing.
Senior specialist Ho Sang Jung, who is responsible for the examination, said, “On account of malignant growths where the determination technique isn’t notable, for example, pancreatic disease, it is hard to recognize and the endurance rate after beginning analysis is low.” It is realized that 14 pancreatic disease patients bite the dust consistently in Korea, and the financial expense per individual is around 63 million won each year.
“Because early conclusion is the most important for hopeless illnesses, such as disease, we anticipate that this innovation will provide another analytic strategy.”
The exploration results were distributed on January 9 in Biosensors and Bioelectronics. The exploration group has applied for related licenses in Korea and the US.
Presently, the group is slowly expanding the sorts of diseases that can be analyzed by investigating the pee of colorectal malignant growth and cellular breakdown in the lungs of patients.
More information: Vo Thi Nhat Linh et al, 3D plasmonic coral nanoarchitecture paper for label-free human urine sensing and deep learning-assisted cancer screening, Biosensors and Bioelectronics (2023). DOI: 10.1016/j.bios.2023.115076
