RUDN physicists got substances with high antibacterial action in view of chitosan and selenium. One of them even beat normal anti-toxins. The outcomes are published in Applied Biochemistry and Microbiology.
Chitosan is a substance derived from the gathering of amino sugars, which is gotten from chitin, the primary part of the arthropod exoskeleton. Because of its natural action, chitosan is utilized, for instance, to make biodegradable films with antibacterial properties or different coatings where anti-toxin activity is required: in food creation, medication, and industry. The extent of chitosan is huge yet restricted. This is because of the low dissolvability and the alleged cationic thickness. To increase it, researchers alter chitosan atoms by adding useful parts to them. RUDN University scientists have “sewn” a selenium-containing part to chitosan and got a profoundly powerful enemy of viral specialists.
“Both S. aureus and E. coli were resistant to the novel compounds’ antibacterial action. Furthermore, their antibacterial activity is equivalent to and even exceeds that of the medicines ampicillin and gentamicin.”
Anton Egorov, RUDN Research Assistant.
“Due to the ascent in antimicrobial resistance, the improvement of new antibacterial specialists is required. This is a vital task of current pharmacology. Chitosan is one of the favored mixtures with antibacterial action. Among its benefits are biocompatibility, hypoallergenicity, biodegradability, and non-tenacity. Simultaneously, unfortunate water solvency and low cationic thickness limit the antibacterial impact of chitosan. To beat these limits, chitosan is changed. “Our objective was the compound change of chitosan with a selenium-containing part,” says Andrey Kritchenkov, Ph.D., scientist at the Department of Inorganic Chemistry, RUDN University.
RUDN physicists got another compound by dissolving chitosan in a selenadiazole subsidiary to various extents. The antibacterial activity of the obtained substances was tested on gram-positive Staphylococcus aureus and gram-negative Escherichia coli, and was compared to the commercial anti-toxins ampicillin and gentamicin.
All blended mixtures showed antibacterial action similar to that of antibio. The X-Se-65 complex with 65% replacement of the selenediazole subsidiary ended up being the best. On a Petri dish, it obliterated Staphylococcus aureus inside a span of 34.4 mm (ampicillin did it inside a range of 30.3 mm), and E. coli was not seen inside a span of 26.3 mm from it (and 22.3 mm from gentamicin).
“The new mixtures have areas of strength for showing action against both S. aureus and E. coli . Also, their antibacterial action is similar to that of the anti-toxins ampicillin and gentamicin, and one of the mixtures even surpassed them. This reality can be made sense of by the harmonious impact of the antibacterial part with selenium and chitosan. “We have got a profoundly dynamic, antibacterial subsidiary of chitosan, which is of undoubted interest for additional in vivo research,” says Anton Egorov, RUDN Research Assistant.
More information: A. R. Egorov et al, Synthesis of Selenium-Containing Chitosan Derivatives and Their Antibacterial Activity, Applied Biochemistry and Microbiology (2022). DOI: 10.1134/S0003683822020053
