Researchers have discovered that the naturally occurring substance hydroquinine has the ability to kill a variety of germs.
One of the biggest global dangers to public health is antimicrobial resistance. It happens when bacteria, viruses, fungi, and parasites evolve over time and stop responding to treatments, making infections challenging to treat.
As a result, the creation of novel antimicrobial medications to fight infections is urgently needed.
A new study by scientists from the University of Portsmouth and Naresuan and Pibulsongkram Rajabhat Universities in Thailand explored whether hydroquinine, which is found in the bark of some trees, could inhibit any bacterial strains.
Although hydroquinine is previously known to be effective against human malaria, little research has been done on its drug-resistant characteristics up until this point.
The research, which was published in the journal Tropical Medicine and Infectious Disease, suggests that the organic chemical may merit further clinical study due to its antibacterial capabilities.
Our future research aims to uncover the molecular target of hydroquinine. This would help our understanding of how the compound works against pathogenic bacteria and how it could potentially be used in a clinical setting.
Dr. Jirapas Jongjitwimol
Dr. Robert Baldock from the School of Pharmacy and Biomedical Sciences at the University of Portsmouth, said: “Using bacterial killing experiments, we found that hydroquinine was able to kill several microorganisms including the common multidrug-resistant pathogen pseudomonas aeruginosa.”
“Characteristically, we also discovered that one of the main mechanisms used by these bacteria to escape killing activity of the drug was upregulated with treatment indicating a robust response from the bacteria. By studying this compound further, our hope is that it may in future offer another line of treatment in combatting bacterial infections.”
More than 2.8 million infections are caused by drug-resistant bacteria, which also cause 35,000 fatalities each year. Common “superbugs” resistant to antibiotics are the root cause of pneumonia, urinary tract infections, and sepsis.
According to statistics, P. aeruginosa bloodstream infections are linked to significant fatality rates of between 30 and 50%. The report suggests more research be done on hydroquinine’s antimicrobial resistance traits and negative effects.
Dr. Jirapas Jongjitwimol from the Department of Medical Technology at Naresuan University added: “Our future research aims to uncover the molecular target of hydroquinine. This would help our understanding of how the compound works against pathogenic bacteria and how it could potentially be used in a clinical setting.”
