Medical research

How aggressive a tumor is or how well a cancer patient reacts to a particular medication can be greatly impacted by a change in only one letter in the coding that makes up a cancer-causing gene. Instead of being constrained to more broadly focused strategies, such as deleting the entire gene, scientists will be able to analyze the impact of these exact genetic modifications in preclinical models thanks to a new, extremely precise gene-editing tool developed by Weill Cornell Medicine investigators. The tool was described in a study published August 10, 2023, in Nature Biotechnology. Weill Cornell Medicine's Dr. Lukas

In comparison to current approaches that rely on manual record checks, an automated procedure that combines natural language processing and machine learning was able to swiftly and accurately identify people who inject drugs (PWID) in electronic health data. Currently, the International Classification of Diseases (ICD) codes are used to identify people who inject drugs. These codes are either entered by healthcare practitioners in patients' electronic health records or are extracted from those data by trained human coders who examine them for billing purposes. However, as there is no unique ICD code for injecting drugs, physicians and coders must utilize a

Brushing two times per day fends the dental specialist off, yet might we at any point enhance the toothpaste we use to keep up with clean teeth, keeping clinical issues that wind up from unfortunate dental wellbeing? Most toothpastes use fluoride, a useful asset for oral cleanliness. Notwithstanding, fluoride can present medical issues at times, particularly for kids who consume a lot of fluoride by gulping a large portion of their toothpaste. To avoid these issues, children typically only use a small amount of toothpaste, which reduces the effectiveness of toothbrushing. In the quest for choices, a group of global

According to a recent Northwestern Medicine study conducted in mice, an epigenetics medicine already used to treat blood malignancies and rare sarcomas can inhibit the progression of bladder cancer by stimulating the immune system. It's the first time a medication intended to treat uncommon sarcomas and hematologic malignancies has been applied to one of the most prevalent solid tumors. The drug, tazemetostat, was originally developed to treat lymphoma. “We've discovered for the first time that the drug actually works by activating the immune system, not just by inhibiting the tumor,” said lead study author Dr. Joshua Meeks, an associate professor

According to a new study by researchers at the University of Colorado Anschutz Medical Campus, a promising new stroke drug that temporarily inhibits a key protein in the brain without causing lasting damage may significantly alter the treatment of cerebral and global ischemia in the future. The study was published in the Journal of Biological Chemistry in May. K. Ulrich Bayer, Ph.D., a senior author of the study and professor of pharmacology at the University of Colorado School of Medicine, stated, "We are one step closer to a new stroke therapy." Our research demonstrates that the neuroprotective effects were significant,

In "The Princess and the Pea," a fairy tale by Hans Christian Andersen published in 1835, the princess is praised for her sensitivity to a pea positioned under 20 mattresses on her bed. A new study from the McKelvey School of Engineering at Washington University in St. Louis has discovered that unlike normal cells, which are unable to sense a layer of cells beneath the top collagen layer on which they normally travel, cancer cells are able to sense this layer, much like the fabled princess. Amit Pathak, an associate professor of mechanical engineering and materials science, and Christopher Walter,

Researchers from AIage Life Science, a probiotics manufacturer in China, looked into the microflora that lives in the guts of centenarians because there is growing scientific evidence showing how the gut microbiota affects human health. In the study, "Longevity of centenarians is reflected by the gut microbiome with youth-associated signatures," which was published in Nature Aging, the researchers looked at the microbiomes of 1,575 people ranging in age from 20 to 117, 297 of whom were reported to be 100 years of age or older. In the same journal issue, a research briefing on the study with the title "Youth-associated

Particularly in the last few decades, changes in how humans live and eat have significantly altered the gut microbiota. Type 2 diabetes, digestive system disorders, allergies, asthma, and other ailments have all been connected to these changes. In an opinion piece that was published on June 30 in the journal Trends in Molecular Medicine, a group from Harvard Medical School and Brigham and Women's Hospital (BWH) makes the suggestion that we can reverse these trends by encouraging people to save samples of their own gut microbiota while they are still young and healthy in case they ever need them for

Neisseria, a genus of bacteria found in the human body, is not as harmless as previously believed and can cause infections in people who have bronchiectasis, asthma, and chronic obstructive pulmonary disease (COPD). An international team of researchers led by Nanyang Technological University, Singapore (NTU Singapore) made this discovery. The scientists provided definitive proof that Neisseria species can infect the lungs and are connected to patients' increasing bronchiectasis (a form of lung disease) in a major study that was published today in Cell Host & Microbe. Up to 50% of Singaporean patients with bronchiectasis experience abnormal enlargement of their pulmonary