According to quantum biologists from the University of Surrey, unlocking the potential of DNA created in the laboratory, also referred to as synthetic DNA, holds the key to revolutionary advancements in a variety of fields.
Synthetic DNA, in contrast to naturally occurring DNA, may make it possible for researchers to create new genes or modify existing ones, thereby opening the door to revolutionary possibilities in biotechnology and medicine. Additionally, synthetic DNA may be able to support Darwinian evolution, opening the door to exciting new insights into genetic systems.
Surrey quantum biologists looked at how protons move in hachimoji DNA, a synthetic form of DNA that has not yet been found in living things, in a novel study.
Utilizing a technique called the “thickness utilitarian hypothesis, the group from Surrey determined the speed at which protons move and how it’s impacted by temperature. They discovered that, in contrast to normal DNA, hachimoji DNA facilitates proton transfer more readily. In particular, protons in hachimoji DNA can move 30% faster than in normal DNA thanks to a specific pair of bases. This suggests that, in comparison to normal DNA, hachimoji DNA might be more susceptible to mutations.
“Exploring hachimoji DNA and its unique properties opens up exciting possibilities for synthetic biology and genetic research. Our findings give light on the kinetics of proton transfer within hachimoji DNA, as well as the possible consequences for mutation rates.”
Dr. Louie Slocombe, lead researcher on the project at the University of Surrey.
Dr. Louie Slocombe, lead analyst on the venture at the College of Surrey, remarked, “The investigation of hachimoji DNA and its particular properties presents invigorating possibilities for engineered science and hereditary exploration. The dynamics of proton transfer within hachimoji DNA are illuminated by our research, which sheds light on its potential effects on mutation rates.
“This information can possibly direct future headway in DNA design and extend our understanding of hereditary frameworks here on our planet and then some.”
Hachimoji DNA is manufactured DNA made in a lab that extends the hereditary code past the standard four letters (A, T, C, and G). It includes four additional building blocks—Z, P, S, and B—that open up new possibilities for genetic research, synthetic biology, and nanotechnology and make genetic information more diverse. Hachimoji DNA is considered a promising candidate for the creation of novel drugs and the engineering of unique organisms.
“The University of Surrey remains committed to pioneering scientific research and driving transformative discoveries,” said co-author Dr. Marco Sacchi from the University of Surrey. The examination concerning hachimoji DNA embodies the College’s greatness in quantum science and the capability of this new field of exploration to disentangle the complexities of hereditary frameworks and outfit the force of creative advancements.”
More information: Harry Warman et al, How proton transfer impacts hachimoji DNA, RSC Advances (2023). DOI: 10.1039/D3RA00983A
