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Bio & Medicine

Bio & Medicine

Scientists have discovered an Immune Cell that fights Bladder Cancer Tumors

Bio & Medicine News
Mount Sinai researchers have made two important discoveries about the mechanism by which bladder cancer cells foil attacks from the immune system. The research, published in Cancer Cell in September, could lead to a new therapeutic option for patients with these types of tumors. Advanced bladder cancer is aggressive and patients generally have poor prognoses. Several immune checkpoint inhibitors have been approved by the Food and Drug Administration for bladder cancer, but they only sustain good responses in about 20 percent of patients. When people get cancer, a type of immune cell called a "natural killer cell" swings into action to try
Bio & Medicine

Improved COVID-19 and HIV Vaccinations may result from a new Nasal Vaccine Delivery Strategy

Bio & Medicine News
Researchers have developed a new method for effectively delivering vaccines via the nose, which could lead to improved protection against diseases such as HIV and COVID-19. An assistant professor at the University of Minnesota is part of a team that has developed a new method for effectively delivering vaccines through mucosal tissues in the nose, which could lead to improved protection against pathogens such as HIV and SARS-CoV-2, the virus that causes COVID-19. The researchers tested the technology on mice and nonhuman primates and discovered that the vaccine elicited strong immune responses, paving the way for further research and development
Bio & Medicine

Discovery of Rare Genetic Mutation in one Family could Lead to improved Diabetes Treatments

Bio & Medicine News
A genetic variation identified in a group of families who are prone to diabetes and kidney failure increases the levels of a type of fat, called ceramides. Therapeutics that prevent this change could be beneficial more broadly to anyone at risk for these conditions. A rare genetic mutation could help explain why some families are more susceptible to diabetes and kidney failure, according to a new study led by University of Utah Health scientists. They say the discovery, made within multiple generations of a single family, could ultimately lead to better treatments for these conditions among a range of patients,
Bio & Medicine

Nanotubes light the path to living photovoltaics.

Bio & Medicine Article
"We put nanotubes within microbes," says teacher Ardemis Boghossian at EPFL's School of Essential Sciences. "That doesn't sound extremely thrilling on a superficial level, yet it's really no joke matter. Scientists have been placing nanotubes in mammalian cells that utilize components like endocytosis that are well defined for such cells. Microorganisms, on the other hand, don't have these systems and face extra difficulties in helping particles through their extreme outer walls. Notwithstanding these obstructions, we've figured out how to make it happen, and this has extremely astonishing ramifications with regards to applications." Boghossian's examination centers around connecting counterfeit nanomaterials with
Bio & Medicine

Key Metabolic Enzyme Inhibition is Effective against Melanoma

Bio & Medicine News
Researchers at Sanford Burnham Prebys, led by Ze'ev Ronai, Ph.D., have shown for the first time that inhibiting a key metabolic enzyme selectively kills melanoma cells and stops tumor growth. Published in Nature Cell Biology, these findings could lead to a new class of drugs to selectively treat melanoma, the most severe form of skin cancer. "We found that melanoma is addicted to an enzyme called GCDH," says Ronai, professor and director of the NCI-designated Cancer Center at Sanford Burnham Prebys. "If we inhibit the enzyme, it leads to changes in a key protein, called NRF2, which acquires its ability to suppress
Bio & Medicine

One day, the world’s tiniest plumbing may be used to deliver medications directly to human cells.

Bio & Medicine Article
Dealing with infinitesimal lines just a millionth as wide as a solitary strand of human hair, Johns Hopkins College specialists have designed a method for guaranteeing that these smallest of lines are protected from the littlest of holes. Release free channeling, made with nanotubes that self-gather, self-fix, and can interface themselves to various biostructures, is a critical stage toward making a nanotube network that one day could convey particular medications, proteins, and particles to designated cells in the human body. The exceptionally exact estimations are framed today in Science Advances. "This review proposes firmly that it's possible to fabricate nanotubes
Bio & Medicine

Therapeutic Viruses Boost the Immune System’s Ability to Fight Cancer

Bio & Medicine News
Researchers propose a new line of attack for treatment-resistant cancers. The immune system has evolved to protect the body from a wide range of potential threats. Among these are bacterial diseases such as plague, cholera, diphtheria, and Lyme disease, as well as viral infections such as influenza, Ebola virus, and SARS CoV-2. Despite the impressive power of the immune system's complex defense network, one type of threat is particularly difficult to combat. This occurs when the body's own native cells go rogue, resulting in cancer. Although the immune system frequently attempts to rid the body of malignant cells, its efforts
Bio & Medicine

Nanopores are being used to detect epigenetic alterations more quickly.

Bio & Medicine Article
Changes known as epigenetic adjustments play a significant part in disease advancement. Having the option to examine them rapidly and dependably could contribute significantly to the further advancement of customized treatment. An examination group from the Institute of Physiology at the University of Freiburg has now prevailed with regards to portraying the compound changes in proteins that are common for epigenetic changes utilizing nanopore examination. The analysts have distributed their exploration in the Journal of the American Chemical Society (JACS). Lately, nanopores have turned into a widely used device for the examination of particles. Because of their unique properties, they
Bio & Medicine

A new platform could make gene medication delivery more convenient and inexpensive.

Bio & Medicine Article
The outcome of COVID-19 immunizations is an incredible illustration of quality medication's huge potential to forestall viral diseases. One reason for the antibodies' prosperity is their utilization of lipid nanoparticles, or LNPs, to convey fragile messenger RNA to cells to create and help resistance. LNPs (small fat particles) have grown in popularity as a transporter for various quality-based medications to cells, but their application is complicated because each LNP must be specifically tailored to the beneficial payload it transports. A group led by Hai-Quan Mao, a Johns Hopkins materials researcher, has made a stage that shows a vow to accelerate
Bio & Medicine

A Nano transistor sensor that analyzes both electrical and mechanical activity in cardiac cells at the same time.

Bio & Medicine News
A University of Massachusetts research team has created an intriguing small sensor that can simultaneously measure electrical and mechanical cell reactions in heart tissue, which could be useful for cardiovascular disease review, drug testing, and regenerative medication. Electrical and PC designing (ECE) Ph.D. understudy Hongyan Gao, first creator of the paper distributed online by the journal Science Advances, depicts the development as "another apparatus for further developed heart concentrates on that has the potential for driving edge applications in cardiovascular illness tests." Since the phone is an essential useful component in science, its mechanical and electrical ways of behaving are
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