Bio & Medicine

Layer partition innovation has been broadly perceived as a more profitable innovation, inferable from its high treatment effectiveness, low impression, and solid emanating quality. However, membrane fouling has hampered its continued, sustainable growth. Although numerous modification strategies have been employed in recent decades to enhance antifouling performance, the resulting membranes typically have a more complex surface chemistry, making it difficult to control membrane fouling. The extremity of particles basically decides their atomic connection. Because their electric dipole moment is close to zero, nonpolar membranes may be better at antifouling because pollutants can't get on the membrane's surface. However, previous studies

The "intelligent" membranes created by researchers at the National Graphene Institute (NGI) have "memory" that can be used in smart separation technology, wound management, drug delivery, sensors, and memory devices. According to Carlsberg/Royal Academy of Engineering Research Chair and study team leader Professor Rahul Raveendran Nair, "the history of membrane development spans more than 100 years and has led to a revolution in industrial separation processes." Some work has been done in recent years to make membranes that look like biological structures, especially those that are "intelligent." Scientists now explain how they created intelligent membranes that can remember how permeable

The intestinal or gut barrier is important for ensuring that nutrients are absorbed and that harmful substances do not enter the bloodstream. Under unhealthy circumstances, the disturbance of the stomach obstruction might increase its penetrability and result in a "defective stomach." The "broken stomach" disorder frequently accompanies side effects like ongoing looseness of the bowels, clogging, or swelling. Numerous illnesses, including inflammatory bowel disease and non-alcoholic fatty liver disease, have been linked to it. While inflammatory bowel disease affects 1-3 out of every 10,000 Singaporeans, both conditions are extremely common in the general population, with the latter affecting approximately 40%

Correlative light electron microscopy (CLEM) is a powerful tool for bioimaging because it combines electron microscopy's high spatial resolution and ultrastructural information with light microscopy's ability to image living cells over large fields of view with molecular specificity. Researchers must ensure that biomolecules of interest are labeled with probes that are visible in both LM (typically by fluorescence) and EM (using electron-dense material) in order to accurately highlight and position them in CLEM. However, there are a number of problems with the probes that are currently available, such as their lack of integrity and stability under LM (photobleaching). A group

Reciprocal light electron microscopy (CLEM) is an integral asset in bioimaging, as it consolidates the capacity to picture living cells over huge fields of view with sub-atomic explicitness by utilizing light microscopy (LM) with the high spatial goal and ultrastructural data of electron microscopy (EM). Researchers must ensure that biomolecules of interest are labeled with probes that are visible in both LM (typically by fluorescence) and EM (using electron-dense material) in order to accurately highlight and position them in CLEM. However, there are a number of problems with the probes that are currently available, such as their lack of integrity

People with type 1 diabetes are at constant risk of hyperglycemia or hypoglycemia. Carefully controlled insulin release helps improve blood sugar control. As reported in the journal Angewandte Chemie, the research team proposed a new formulation of glucose-linked insulin, a lipid nanoparticle carrier that releases more or less insulin depending on blood glucose levels. Plasma insulin levels are primarily regulated by pancreatic  cells and reflect fluctuations in blood glucose levels. People with type 1 diabetes make little or no insulin and need several injections of short-acting insulin and one or two injections of long-acting insulin daily to maintain normal blood

A perfect nanovesicle for fighting cancer would have three functions: 1) a precision-targeting molecule to preferentially bind it to surface markers on cancer cells, 2) a strongly bound radionuclide signal to locate the vesicles in the body, and 3) the capacity to carry and release a drug treatment, such as chemotherapy, at the cancer tumor. It would also satisfy two additional requirements, including having an easy and straightforward manufacturing process and being biocompatible and biodegradable in the body. A small polymersome that appears to overcome these obstacles in preliminary preclinical experiments has now been described by a team from the

Although the Pfizer-BioNTech and Moderna mRNA COVID-19 vaccines are safe and effective at preventing severe illness in adults and children, including immunocompromised individuals, researchers have observed that these shots continue to be more efficient and effective in younger individuals than in older adults. Lipid nanoparticles, or LNPs, a crucial component of these vaccines that delivers the mRNA cargo to cells, including cells of the innate immune system (or response cells), were the subject of research at the Perelman School of Medicine at the University of Pennsylvania and the College of Medicine at Drexel University. These researchers demonstrated that LNPs can

Think how unpleasant it is to wrap a gift in a box that is too small. Sometimes you just need a bigger box. Nanostructures are small artificial containers that can be used to deliver therapeutic drugs to specific areas of the body. But some drug molecules are like gifts: too big for standard-size nanocage "boxes". Now, in a paper published today (April 6) in Nature Synthesis, researchers at the University of Cambridge describe how they built ultra-large nanocages that could be used to deliver even larger cargoes of drugs. simple building blocks. The rational management of self-assembly cages of this

Treatments involving chemotherapy have significant side effects. This issue is not present with a novel agent that builds up within the tumor tissue and is activated there by ultrasound waves. Platinum complexes are among the most frequently prescribed cancer treatments. Although effective, they have negative side effects. A complex that builds up in tumor tissue and is activated there by ultrasound waves has been created by an international research team under the direction of Dr. Johannes Karges from the Faculty of Chemistry and Biochemistry at Ruhr University Bochum, Germany. Thus, its cell-damaging effect only manifests where it is actually desired.