Biomedical technology

The "missing millions" are the estimated three million undiagnosed cases of tuberculosis (TB) worldwide each year, according to the World Health Organization. A cutting-edge study has tested a diagnostic device that uses dielectrophoretic and has the potential to improve the detection and treatment of tuberculosis in underserved, high-endemic areas. Global targets for reducing the burden of tuberculosis will be met by providing diagnostics to the most in need patients. The findings of the study are published in The Journal of Molecular Diagnostics. The opportunity to prioritize the development of a low-cost, fast, accurate, and portable TB diagnostic test for analyzing

Nanotechnology has been found to improve the effectiveness of chemotherapy. People who are likely to develop peritoneal cancer in the future may benefit from the new research. Astrid Hyldbakk, who recently completed her doctorate at NTNU's Department of Physics, asserts that "this patient group needs more effective treatment methods." She is now working as a researcher in biotechnology and nanomedicine for SINTEF Industries. The peritoneal cavity is frequently affected by cancer that has spread to the stomach and intestines. Because it is difficult to detect peritoneal cancer, the disease frequently progresses long before treatment begins. Sadly, the treatment methods frequently

Minimally invasive techniques that allow for images of delicate deep-brain tissues are required to investigate the activity of neuronal structures and the interaction of nerve cells. An international team and Leibniz IPHT collaborated on the development of a new hair-thin endomicroscope that promises extremely gentle in-depth observations, the ability to investigate specific regions of the brain, and the onset and progression of severe neuronal diseases. Neuroscientists hope that the instrument will assist them in developing novel approaches to combating these debilitating conditions. The findings were published by the researchers in Nature Communications. Neuronal sicknesses like chemical imbalance, epilepsy, Alzheimer's, or,

Although there is currently no treatment for heart failure, the condition is prevalent. Additionally, treatments can only alleviate symptoms and frequently cause side effects. However, focusing on cardiac fibrosis—a condition that frequently precedes heart failure—in recent research that was published in ACS Biomaterials Science & Engineering may open up new avenues toward potential therapies. A more accurate model of this "scarred" cardiac tissue has been created by researchers, which may facilitate faster drug testing. Heart failure affects millions of people when the heart is unable to pump enough blood to support the body. Outrageous cases can require medical procedures or

One of the most detailed 3D images of the synapse, the crucial junction where neurons exchange chemical signals, has been created by researchers. Neurodegenerative diseases like Huntington's and schizophrenia can be better understood and studied with the assistance of these nanometer-scale models. A team led by Steve Goldman, MD, Ph.D., co-director of the Center for Translational Neuromedicine at the University of Rochester and the University of Copenhagen, published the new study in PNAS. The findings are a significant technical accomplishment that enables researchers to examine the various cells that converge at individual synapses in unprecedented depth. Abdellatif Benraiss, Ph.D., a

According to a study published in the June 14 issue of Science Advances by researchers from the University of Connecticut, a new, biodegradable ultrasound that is significantly more powerful than previous devices could make brain cancer more treatable. The American Cancer Society estimates that more than 18,000 Americans will die from brain cancer in 2023. Each year, more than 24,000 Americans are diagnosed with the disease. When a person is told they have a cancerous brain tumor, the tumor is usually removed surgically, and chemotherapy is used to get rid of the cancer cells that are still there. However, the

The mammalian brain's prefrontal cortex (PFC) is known to be involved in decision-making, planning, complex social behavior, and integrating other brain regions' activity. Numerous neuroscience studies have examined the function and structure of this crucial brain region, but little is known about how its neurons are organized. Dendrites, which are branches extending from neurons that receive impulses from other neurons, and axons, which are regions of neurons that generate and transmit impulses, are the subjects of recent research at the Chinese Academy of Sciences aimed at gaining a deeper comprehension of the PFC's organization. They used a novel tool to

A potential replacement for mesh implants and internal stitches could be a new antibacterial suture material that glows in medical imaging. One of the most prevalent medical infections is a surgical site infection, which affects 2 to 4% of patients after surgery. Infection rates may be higher for particular treatments, such as vaginal mesh implants to treat prolapse. Study lead author and Vice Chancellor's Senior Research Fellow, Dr. Shadi Houshyar, said their suture was being developed in partnership with clinicians specifically for this type of procedure. “Our smart surgical sutures can play an important role in preventing infection and monitoring

A method that may help identify Parkinson's disease symptoms in urine samples has been developed by a group led by researchers at Purdue University and Tymora Analytical Operations, a spinoff of Purdue. LRRK2 (leucine-rich repeat kinase 2) proteins, which are linked to Parkinson's disease, and their downstream pathways may be altered in Parkinson's patient samples using this method. The strategy could ultimately prompt far and wide painless testing for other neurodegenerative circumstances as well as disease. W. Andy Tao, a professor of biochemistry at Purdue, stated, "We believe this is a logical and rational approach to move forward for the